J Enzyme Inhib Med Chem. 2020 Dec;35(1):657-664. doi: 10.1080/14756366.2020.1733547.
In vivo antiaging effects of alkaline water supplementation.
Abstract
Telomeres length and telomerase activity are
currently considered aging molecular stigmata. Water is a major requirement for
our body and water should be alkaline. Recent reports have shown that aging is
related to a reduced water intake. We wanted to investigate the effect of the
daily intake of alkaline water on the molecular hallmark of aging and the
anti-oxidant response. We watered a mouse model of aging with or without
alkaline supplementation. After 10 months, we obtained the blood, the bone
marrow and the ovaries from both groups. In the blood, we measured the levels
of ROS, SOD-1, GSH, and the telomerase activity and analysed the bone marrow
and the ovaries for the telomeres length. We found reduced ROS levels
and increased SOD-1, GSH, telomerase activity and telomeres length in alkaline supplemented mice. We show here that watering by
using alkaline water supplementation highly improves aging at the molecular
level.
KEYWORDS:
Alkaline water supplementation; antiaging; antioxidant effect; telomerase; telomeres length
Effect of resveratrol and pterostilbene on aging and longevity.
Abstract
Over the past years, several studies have found that foods rich in
polyphenols protect against age-related disease, such as atherosclerosis,
cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2
diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and
pterostilbene, the polyphenol found in grape and blueberries, have beneficial
effects as anti-aging compounds through modulating the hallmarks of aging,
including oxidative damage, inflammation, telomere attrition and cell
senescence. In this review, we discuss the relationship between resveratrol and
pterostilbene and possible aging biomarker, including oxidative stress,
inflammation, and high-calorie diets. Moreover, we also discuss the positive
effect of resveratrol and pterostilbene on lifespan, aged-related disease, and
health maintenance. Furthermore, we summarize a variety of important mechanisms
modulated by resveratrol and pterostilbene possibly involved in attenuating
age-associated disorders. Overall, we describe resveratrol and pterostilbene
potential for prevention or treatment of several age-related diseases by
modulating age-related mechanisms.
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Clin Nutr. 2006
Jun;25(3):377-85. Epub 2005 Nov 28.
Water, mineral waters and health.
Author information
Abstract
The authors focus on water resources and the
use of mineral waters in human nutrition, especially in the different stages of
life, in physical activity and in the presence of some morbid conditions.
Mineral water is characterized by its purity at source, its content in
minerals, trace elements and other constituents, its conservation and its
healing properties recognized by the Ministry of Health after clinical and
pharmacological trials. Based on total salt content in grams after evaporation
of 1l mineral water dried at 180 degrees C (dry residues), mineral waters can
be classified as: waters with a very low mineral content, waters low in mineral
content, waters with a medium mineral content, and strongly mineralized waters.
Based on ion composition mineral waters can be classified as: bicarbonate
waters, sulfate waters, sodium chloride or saltwater, sulfuric waters. Based on
biological activity mineral waters can be classified as: diuretic waters,
cathartic waters, waters with antiphlogistic properties. Instructions for use,
doses, and current regulations are included.
